Sustained remission of multiple myeloma achieved after personalized cellular therapy

September 10, 2015 by · Leave a Comment 

A multiple myeloma patient whose cancer had stopped responding after nine different treatment regimens experienced a complete remission after receiving an investigational personalized cellular therapy known as CTL019 developed by a team at the University of Pennsylvania. The investigational treatment was combined with chemotherapy and an autologous stem cell transplant – a new strategy designed to target and kill the cells that give rise to myeloma cells.

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Programming adult stem cells to treat muscular dystrophy and more by mimicking nature

July 22, 2015 by · Leave a Comment 

Stem cells hold great potential for addressing a variety of conditions from spinal cord injuries to cancer, but they can be difficult to control. Scientists are now reporting in the journal ACS Nano a new way to mimic the body’s natural approach to programming these cells. Using this method, they successfully directed adult stem cells to turn specifically into muscle, which could potentially help treat patients with muscular dystrophy.

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Stem cell therapy shows promise in small clinical trial for rare lung disease

July 21, 2015 by · Leave a Comment 

Canadian researchers have published promising results of the first clinical trial in the world of a genetically-enhanced stem cell therapy for pulmonary arterial hypertension (PAH). This rare and deadly disease mainly affects young women, and is characterized by very high pressure in the arteries supplying blood to the lungs. In some cases, PAH is caused by a defective gene, but in many cases the cause is unknown. Currently available drugs can modestly improve symptoms and exercise capacity (at best), but cannot repair the blood vessel damage to the lungs or cure the disease.

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Supercharging stem cells to create new therapies

July 6, 2015 by · Leave a Comment 

Researchers at the University of Adelaide have discovered a new method for culturing stem cells which sees the highly therapeutic cells grow faster and stronger.

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Nanoparticles target and kill cancer stem cells that drive tumor growth

June 11, 2015 by · Leave a Comment 

Many cancer patients survive treatment only to have a recurrence within a few years. Recurrences and tumor spreading are likely due to cancer stem cells that can be tough to kill with conventional cancer drugs. But now researchers have designed nanoparticles that specifically target these hardy cells to deliver a drug. The nanoparticle treatment, reported in the journal ACS Nano, worked far better than the drug alone in mice.

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Stem cells lurking in tumors can resist treatment

March 13, 2015 by · Leave a Comment 

Scientists are eager to make use of stem cells’ extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. Malignant tumors contain stem cells, prompting worries among medical experts that the cells’ transformative powers help cancers escape treatment.

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Research: NFL athletes are seeking unproven stem cell treatments

December 5, 2014 by · Leave a Comment 

Some National Football League (NFL) players have been seeking out unproven stem cell therapies to help accelerate recoveries from injuries, according to a new paper from Rice University’s Baker Institute for Public Policy. While most players seem to receive treatment within the United States, several have traveled abroad for therapies unavailable domestically and may be unaware of the risks involved, the paper found.

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Study urges caution in stem cell clinical trials for heart attack patients

May 7, 2014 by · Leave a Comment 

A new study in Nature challenges research data that form the scientific basis of clinical trials in which heart attack patients are injected with stem cells to try and regenerate damaged heart tissue.

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stem cells derived from human body fat uman fat: A trojan horse to fight brain cancer?

May 1, 2014 by · Leave a Comment 

Johns Hopkins researchers say they have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives.

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Converting adult human cells to hair-follicle-generating stem cells

January 28, 2014 by · Leave a Comment 

If the content of many a situation comedy, not to mention late-night TV advertisements, is to be believed, there’s an epidemic of balding men, and an intense desire to fix their follicular deficiencies.

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