Stem cell transplantation for children with rare form of leukemia improves outcomes

July 24, 2015 by · Leave a Comment 

Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at Children’s Hospital Los Angeles have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia (JMML).

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Scientists find way to disrupt brain tumor stem cells

June 12, 2015 by · Leave a Comment 

ome brain tumors are notoriously difficult to treat. Whether surgically removed, zapped by radiation or infiltrated by chemotherapy drugs, they find a way to return.

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Odd histone helps suppress jumping genes in stem cells, study says

May 5, 2015 by · Leave a Comment 

A family of proteins known as histones provides support and structure to DNA, but for years, scientists have been puzzling over occasional outliers among these histones, which appear to exist for specific, but often mysterious reasons. Now, researchers have uncovered a new purpose for one such histone variant: preventing genetic mutations by keeping certain so-called “jumping genes” in place.

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First embryonic stem cell therapy safety trial in Asian patients

May 3, 2015 by · Leave a Comment 

A clinical trial in the Republic of Korea for patients with degenerative eye diseases is the first to test the safety of an embryonic stem cell therapy for people of Asian descent. The study, which followed four individuals for a year after they were treated with embryonic stem cell-derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy. The researchers report the results on April 30 inStem Cell Reports, the journal of theInternational Society for Stem Cell Research.

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Stem cells faulty in Duchenne muscular dystrophy, Stanford researchers find

December 18, 2014 by · Leave a Comment 

Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers at the Stanford University School of Medicine have found that the fault may lie at least partly in the stem cells that surround the muscle fibers.

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Patient-specific stem cells and personalized gene therapy

July 10, 2014 by · Leave a Comment 

Columbia University Medical Center (CUMC) researchers have created a way to develop personalized gene therapies for patients with retinitis pigmentosa (RP), a leading cause of vision loss. The approach, the first of its kind, takes advantage of induced pluripotent stem (iPS) cell technology to transform skin cells into retinal cells, which are then used as a patient-specific model for disease study and preclinical testing.

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Spinal cord mass arising from neural stem cell therapy

July 8, 2014 by · Leave a Comment 

A spinal mass was identified in a young woman with complete spinal cord injury 8 years after she had undergone implantation of olfactory mucosal cells in the hopes of regaining sensory and motor function. The case is reported and discussed in “Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient. Case report,” by Brian J. Dlouhy, MD, Olatilewa Awe, MD, Rajesh C. Rao, MD, Patricia A. Kirby, MD, and Patrick W. Hitchon, MD, published today online, ahead of print, in theJournal of Neurosurgery: Spine. The authors state that this is the first report of a spinal cord mass arising from spinal cord cell transplantation and neural stem cell therapy, and they caution that physicians should be vigilant in their follow-up of patients who undergo stem cell interventions.

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Dental pulp stem cells promote the survival and regeneration of retinal cells after injury

July 8, 2014 by · Leave a Comment 

Researchers at the University of Birmingham, UK, led by Dr. Ben Scheven, Dr. Wendy Leadbeater and Ben Mead have discovered that stem cells isolated from the teeth, termed dental pulp stem cells (DPSC), can protect retinal ganglion cells (RGCs) from death following injury and promote regeneration of their axons along the optic nerve.

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Some stem cell methods closer to ‘gold standard’ than others

July 5, 2014 by · Leave a Comment 

LA JOLLA-Researchers around the world have turned to stem cells, which have the potential to develop into any cell type in the body, for potential regenerative and disease therapeutics.

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Stem cells may be more widespread and with greater potential than previously believed

July 2, 2014 by · Leave a Comment 

With the plethora of research and published studies on stem cells over the last decade, many would say that the definition of stem cells is well established and commonly agreed upon. However, a new review article appearing in the July 2014 issue of The FASEB Journal , suggests that scientists have only scratched the surface of understanding the nature, physiology and location of these cells. Specifically, the report suggests that embryonic and induced pluripotent stem cells may not be the only source from which all three germ layers in the human body (nerves, liver or heart and blood vessels) can develop. The review article suggests that adult pluripotent stem cells are located throughout the body and are able to become every tissue, provided these cells receive the right instructions.

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