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Stem cell transplantation for children with rare form of leukemia improves outcomes

July 24, 2015 by · Leave a Comment 

Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at Children’s Hospital Los Angeles have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia (JMML).

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Spinal cord injury victims may benefit from stem cell transplantation studies

October 15, 2014 by · Leave a Comment 

Two studies recently published in Cell Transplantation reveal that cell transplantation may be an effective treatment for spinal cord injury (SCI), a major cause of disability and paralysis with no current restorative therapies.

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Future heat stroke treatment found in dental pulp stem cells

June 7, 2014 by · Leave a Comment 

Scientists in Taiwan have found that intravenous injections of stem cells derived from human exfoliated deciduous tooth pulp (SHED) have a protective effect against brain damage from heat stroke in mice. Their finding was safe and effective and so may be a candidate for successfully treating human patients by preventing the neurological damage caused by heat stroke.

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Transplanted human umbilical cord blood cells improved heart function in rat model of MI

March 6, 2014 by · Leave a Comment 

When human umbilical cord blood cells were transplanted into rats that had undergone a simulated myocardial infarction (MI), researchers investigating the long term effects of the transplantation found that left ventricular (LV) heart function in the treated rats was improved over those that did not get the stem cells. The animals were maintained without immunosuppressive therapy.

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Stem cells injected into nerve guide tubes repair injured peripheral nerve

January 13, 2014 by · Leave a Comment 

Using skin-derived stem cells (SDSCs) and a previously developed collagen tube designed to successfully bridge gaps in injured nerves in rat models, the research team in Milan, Italy that established and tested the procedure has successfully rescued peripheral nerves in the upper arms of a patient suffering peripheral nerve damage who would have otherwise had to undergo amputations.

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Liver cells benefit from mesenchymal stem cell co-culture prior to transplantation

December 19, 2013 by · Leave a Comment 

Hepatocyte (liver cell) transplantation is becoming an accepted therapy for acute liver failure, either for liver regeneration or as a bridge to liver transplantation. However, maintaining the viability and functional aspects of hepatocytes has been a concern even with successful freezing (cryopreservation). In an effort to improve both the viability and function of cryopreserved hepatocytes prior to transplantation, researchers at Kings College Hospital, London, have co-cultured hepatocytes along with human mesenchymal stem cells (MSCs) derived from umbilical cord or fat tissues and found that the co-culturing confers improved hepatocyte survival and function.

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Advances in stem cell transplantation strategies show promise to improve availability, success

December 7, 2013 by · Leave a Comment 

Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies. Several studies representing these advances were presented today during the 55th American Society of Hematology Annual Meeting and Exposition in New Orleans.

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Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation

July 23, 2013 by · Leave a Comment 

When melatonin, a hormone secreted by the pineal gland, was used as a pre-treatment for mesenchymal stem cells (MSCs) prior to their transplantation into the brains of laboratory animals to repair damage from stroke, researchers in China found that the stem cells survived longer after transplantation. Previous studies had shown that 80 percent of transplanted MSCs died within 72 hours of transplantation. By contrast, the melatonin pre-treatment “greatly increased” cell survival, said the researchers.

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Pluripotent stem cell-derived neurons may be a viable Parkinson’s disease treatment

June 30, 2013 by · Leave a Comment 

A team of researchers from Rush University, Yale University, the University of Colorado and the St. Kitts Biomedical Research Foundation transplanted human embryonic stem cells into primate laboratory animals modeled with Parkinson’s disease and found “robust survival” of the cells after six weeks and indications that the cells were “well integrated” into the host animals. The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line athttp://www.ingentaconnect.com/content/cog/ct/pre-prints/ct1000wakeman.

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