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Protein identified that favors neuroprotective glial cell formation from stem cells

August 7, 2015 by · Leave a Comment 

An international team of researchers has shown that NFIX, a protein that regulates neuronal stem cell activity (NSC), also has a role in driving NSC differentiation toward oligodendrocytes, a type of glial cell. These cells produce the myelin that surrounds and protects neurons. Evidence supporting this mechanism in mice and its potential in the development of NSC-based therapy for brain injury, demyelinating diseases, and brain tumors are discussed in a study published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Development website until September 6, 2015.

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New method for reducing tumorigenicity in induced pluripotent stem-cell based therapies

July 24, 2014 by · Leave a Comment 

The potential for clinical use of induced pluripotent stem cell (iPSC) technology for transplant-based therapeutic strategies has previously been hindered by the risk of dysregulated cell growth, specifically the development of tumors. The ability to use etoposide treatment to halt teratoma formation in iPSCs for the treatment of heart disease, specifically acute myocardial infarction, is demonstrated in an article in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Stem Cells and Development website.

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Inner ear stem cells hold promise for restoring hearing

June 22, 2014 by · Leave a Comment 

Spiral ganglion cells are essential for hearing and their irreversible degeneration in the inner ear is common in most types of hearing loss. Adult spiral ganglion cells are not able to regenerate. However, new evidence in a mouse model shows that spiral ganglion stem cells present in the inner ear are capable of self-renewal and can be grown and induced to differentiate into mature spiral ganglion cells as well as neurons and glial cells, as described in an article inBioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

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First evidence that very small embryonic-like stem cells

April 1, 2014 by · Leave a Comment 

Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two articles in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The articles are available on the Stem Cells and Development website.

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New method yields potent, renewable human stem cells with promising therapeutic properties

March 26, 2014 by · Leave a Comment 

The curative and therapeutic potential of mesenchymal stem cells (MSCs) offers much promise, as these multipotent cells are currently being tested in more than 300 clinical trials in a range of diseases. A new, easier, and more reliable way to make large quantities of highly potent MSCs could accelerate progress toward their use in regenerative medicine, as described in an article in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Stem Cells and Development website.

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Critical factor (BRG1) identified for maintaining stem cell pluripotency

February 9, 2014 by · Leave a Comment 

he ability to reprogram adult cells so they return to an undifferentiated, pluripotent state—much like an embryonic stem cell—is enabling the development of promising new cell therapies. Accelerating progress in this field will depend on identifying factors that promote pluripotency, such as the Brg1 protein described in a new study published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

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New recombinant antibody can isolate stem cells from umbilical cord blood

September 3, 2013 by · Leave a Comment 

A new recombinant antibody can detect and isolate mesenchymal stem cells (MSCs), a nonembryonic source of stem cells with promising applications in tissue engineering, blood stem cell transplantation, and treatments for immune-mediated disorders. The antibody recognizes an i blood group antigen present on MSCs in umbilical cord blood, as described in a study published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc.,publishers. The article is available free on the BioResearch Open Access website.

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New method for creating long-lived stem cells used for bone replacement

December 5, 2012 by · Leave a Comment 

Human mesenchymal stem cells (hMSCs) can develop into bone cells and are useful for tissue engineering and regeneration. However, when grown in the laboratory they quickly lose their ability to continue dividing and they die. A method for genetically engineering hMSCs so they become immortal and still retain their ability to become bone cells is described in an article published in BioResearch Open Access, a bimonthly peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website at http://www.liebertpub.com/biores.

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