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Sleep deprivation affects stem cells, reducing transplant efficiency, study finds

October 14, 2015 by · Leave a Comment 

Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine.

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Johns Hopkins biologist leads research shedding light on stem cells

October 8, 2015 by · Leave a Comment 

A Johns Hopkins University biologist has led a research team reporting progress in understanding the mysterious shape-shifting ways of stem cells, which have vast potential for medical research and disease treatment.

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Restoring vision with stem cells

October 8, 2015 by · Leave a Comment 

Age-related macular degeneration (AMRD) could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital. ARMD is a common eye problem caused by the loss of cones. Bernier’s team has developed a highly effective in vitro technique for producing light sensitive retina cells from human embryonic stem cells. “Our method has the capacity to differentiate 80% of the stem cells into pure cones,” Professor Gilbert explained. “Within 45 days, the cones that we allowed to grow towards confluence spontaneously formed organised retinal tissue that was 150 microns thick. This has never been achieved before.”

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Scientists sequence genome of worm that can regrow body parts, seeking stem cell insights

September 22, 2015 by · Leave a Comment 

Tourists spending a recuperative holiday on the Italian coast may be envious of the regenerative abilities of locally found flatworm Macrostomum lignano. Named for its discovery near the Italian beach town of Lignano Sabbiadoro, this tiny worm can regenerate almost its whole body following an injury, and researchers have long been trying to understand how it’s able to pull off this trick.

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Discovery offers hope for treating leukemia relapse post-transplant

September 11, 2015 by · Leave a Comment 

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.

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Variations in cell programs control cancer and normal stem cells

September 3, 2015 by · Leave a Comment 

In the breast, cancer stem cells and normal stem cells can arise from different cell types but tap into distinct yet related stem cell programs, according to Whitehead Institute researchers. The differences between these stem cell programs may be significant enough to be exploited by future therapeutics.

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Stem cells help researchers study the effects of pollution on human health

August 10, 2015 by · Leave a Comment 

A recent study published in the Journal of Environmental Sciences (JES) shows that embryonic stem cells could serve as a model to evaluate the physiological effects of environmental pollutants efficiently and cost-effectively.

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NYSCF Global Stem Cell ArrayTM brings precision medicine one step closer to the clinic

August 3, 2015 by · Leave a Comment 

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells. This unique platform, the NYSCF Global Stem Cell ArrayTM, for the first time gives researchers the scale to look at diverse populations to better understand the underlying causes of disease and create new individually tailored treatments, enabling precision medicine in patient care.

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T-cell receptor therapy achieves encouraging clinical responses in multiple myeloma

July 21, 2015 by · Leave a Comment 

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person’s own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT). This time, researchers modified T cells to attack cancer cells expressing NY-ESO-1, an antigen found in nearly 60 percent of multiple myelomas and previously shown to be associated with tumor growth and poor prognosis.

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Certain donors with high T cell counts make better match for stem-cell transplant patients

June 9, 2015 by · Leave a Comment 

Using a simple blood test to measure the T lymphocyte count in donors for stem cell transplants may help identify the best match for patients in need of an allogeneic stem cell transplant, suggests a new study in the Journal of Clinical Oncology from researchers at the Abramson Cancer Center (ACC) of the University of Pennsylvania. Typically, matched siblings have been preferred over unrelated donors. This study shows that older patients who received stem cells from younger, unrelated donors with higher numbers of so-called killer T cells (CD8 cells) had significantly reduced risk of disease relapse and improved survival compared to those who received stem-cells from donors with low numbers of CD8 cells, including older matched siblings.

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