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Cryptic clues drive new theory of bowel cancer development

October 17, 2014 by · Leave a Comment 

Melbourne researchers have challenged conventional thinking on how the bowel lining develops and, in the process, suggested a new mechanism for how bowel cancer starts.

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New blood: Tracing the beginnings of hematopoietic stem cells

August 15, 2014 by · Leave a Comment 

Hematopoietic stem cells (HSCs) give rise to all other blood cell types, but their development and how their fate is determined has long remained a mystery. In a paper published online this week in Nature, researchers at the University of California, San Diego School of Medicine elaborate upon a crucial signaling pathway and the role of key proteins, which may help clear the way to generate HSCs from human pluripotent precursors, similar to advances with other kinds of tissue stem cells.

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Cell discovery brings blood disorder cure closer

August 13, 2014 by · Leave a Comment 

A cure for a range of blood disorders and immune diseases is in sight, according to scientists who have unravelled the mystery of stem cell generation.

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Using geometry, researchers coax human embryonic stem cells to organize themselves

July 2, 2014 by · Leave a Comment 

About seven days after conception, something remarkable occurs in the clump of cells that will eventually become a new human being. They start to specialize. They take on characteristics that begin to hint at their ultimate fate as part of the skin, brain, muscle or any of the roughly 200 cell types that exist in people, and they start to form distinct layers.

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Scientists identify link between stem cell regulation and the development of lung cancer

June 20, 2014 by · Leave a Comment 

UCLA researchers led by Dr. Brigitte Gomperts have discovered the inner workings of the process thought to be the first stage in the development of lung cancer. Their study explains how factors that regulate the growth of adult stem cells that repair tissue in the lungs can lead to the formation of precancerous lesions.

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Open science journal publishes attempt to reproduce high-profile stem cell acid bath study

May 8, 2014 by · Leave a Comment 

In a study published today in F1000Research, Professor Kenneth Lee of the Chinese University of Hong Kong reveals the full experimental results of an attempt to replicate a controversial study published in Nature recently that suggested that bathing somatic cells in acid can reprogram them to induced pluripotent stem cells (iPS cells). With systematically collected and fully available data, Lee and his colleagues report that carefully replicating the original acid-treatment method does not induce pluripotency in two types of mouse somatic cells, including those used in the original study.

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One step closer to cell reprogramming

May 7, 2014 by · Leave a Comment 

In 2012, John B. Gurdon and Shinya Yamakana were awarded the Nobel Prize in medicine for discovering that adult cells can be reprogrammed into pluripotent ones (iPS); the cells obtained are capable of behaving in a similar way to embryonic stem cells, and hence have enormous potential for regenerative medicine.

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Cedars-Sinai researchers identify how heart stem cells orchestrate regeneration

May 7, 2014 by · Leave a Comment 

Investigators at the Cedars-Sinai Heart Institute – whose previous research showed that cardiac stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack in humans – have identified components of those stem cells responsible for the beneficial effects.

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How a Silly Putty ingredient could advance stem cell therapies

April 14, 2014 by · Leave a Comment 

The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become, a University of Michigan study shows.

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Team finds a better way to grow motor neurons from stem cells

April 1, 2014 by · Leave a Comment 

Researchers report they can generate human motor neurons from stem cells much more quickly and efficiently than previous methods allowed. The finding, described in Nature Communications, will aid efforts to model human motor neuron development, and to understand and treat spinal cord injuries and motor neuron diseases such as amyotrophic lateral sclerosis (ALS).

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