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NYSCF Global Stem Cell ArrayTM brings precision medicine one step closer to the clinic

August 3, 2015 by · Leave a Comment 

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells. This unique platform, the NYSCF Global Stem Cell ArrayTM, for the first time gives researchers the scale to look at diverse populations to better understand the underlying causes of disease and create new individually tailored treatments, enabling precision medicine in patient care.

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Stem cell therapy shows promise in small clinical trial for rare lung disease

July 21, 2015 by · Leave a Comment 

Canadian researchers have published promising results of the first clinical trial in the world of a genetically-enhanced stem cell therapy for pulmonary arterial hypertension (PAH). This rare and deadly disease mainly affects young women, and is characterized by very high pressure in the arteries supplying blood to the lungs. In some cases, PAH is caused by a defective gene, but in many cases the cause is unknown. Currently available drugs can modestly improve symptoms and exercise capacity (at best), but cannot repair the blood vessel damage to the lungs or cure the disease.

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Scientist at LIMR leads study demonstrating drug-induced tissue regeneration

June 4, 2015 by · Leave a Comment 

A study led by Ellen Heber-Katz, PhD, of the Lankenau Institute for Medical Research (LIMR), part of Main Line Health (MLH), shows that a primordial form of energy production that still exists in mammals can be harnessed to achieve spontaneous tissue regeneration in mice, without the need for added stem cells. The study findings were reported in the June 3, 2015, issue of Science Translational Medicine, a peer-reviewed journal of the American Association for the Advancement of Science. Key collaborators in the study, which was supported by grants from the National Institutes of Health, included Yong Zhang, PhD (LIMR), Iossif Strehin, PhD (Allergan), and Phillip Messersmith, PhD (University of California, Berkeley).

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Drugs stimulate body’s own stem cells to replace brain cells lost in multiple sclerosis

April 21, 2015 by · Leave a Comment 

A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis.

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Stanford team makes switching off cells with light as easy as switching them on

April 25, 2014 by · Leave a Comment 

In 2005, a Stanford University scientist discovered how to switch brain cells on or off with light pulses by using special proteins from microbes to pass electrical current into neurons.

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3-D biomimetic scaffolds support regeneration of complex tissues from stem cells

January 10, 2013 by · Leave a Comment 

Stem cells can be grown on biocompatible scaffolds to form complex tissues such as bone, cartilage, and muscle for repair and regeneration of damaged or diseased tissue. However, to function properly, the cells must often grow in a specific pattern or alignment. An innovative method for creating a stretched polymer scaffold that can support complex tissue architectures is described in an article in Tissue Engineering, Part C, Methods, a peer-reviewed journal fromMary Ann Liebert, Inc., publishers. The article is available on the Tissue Engineering, Part C, Methods website.

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Bush embryonic stem cell lines different from newly derived cell lines

November 30, 2011 by · Leave a Comment 

Established human embryonic cell lines, including those approved for federal research funding under former President George W. Bush, are different than newly derived human embryonic stem cell lines, according to a study by UCLA stem cell researchers.

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