Scientist at LIMR leads study demonstrating drug-induced tissue regeneration

June 4, 2015 by · Leave a Comment 

A study led by Ellen Heber-Katz, PhD, of the Lankenau Institute for Medical Research (LIMR), part of Main Line Health (MLH), shows that a primordial form of energy production that still exists in mammals can be harnessed to achieve spontaneous tissue regeneration in mice, without the need for added stem cells. The study findings were reported in the June 3, 2015, issue of Science Translational Medicine, a peer-reviewed journal of the American Association for the Advancement of Science. Key collaborators in the study, which was supported by grants from the National Institutes of Health, included Yong Zhang, PhD (LIMR), Iossif Strehin, PhD (Allergan), and Phillip Messersmith, PhD (University of California, Berkeley).

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Converting adult human cells to hair-follicle-generating stem cells

January 28, 2014 by · Leave a Comment 

If the content of many a situation comedy, not to mention late-night TV advertisements, is to be believed, there’s an epidemic of balding men, and an intense desire to fix their follicular deficiencies.

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Pluripotent cells from pancreatic cancer cells first human model of cancer’s progression

June 21, 2013 by · Leave a Comment 

Pancreatic cancer carries a dismal prognosis. According to the National Cancer Institute, the overall five-year relative survival for 2003-2009 was 6 percent.

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Turning human stem cells into brain cells sheds light on neural development

May 2, 2013 by · Leave a Comment 

Medical researchers have manipulated human stem cells into producing types of brain cells known to play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia and autism. The new model cell system allows neuroscientists to investigate normal brain development, as well as to identify specific disruptions in biological signals that may contribute to neuropsychiatric diseases.

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Monell scientists identify elusive taste stem cells

February 4, 2013 by · Leave a Comment 

Scientists at the Monell Center have identified the location and certain genetic characteristics of taste stem cells on the tongue. The findings will facilitate techniques to grow and manipulate new functional taste cells for both clinical and research purposes.

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Drug resistant leukemia stem cells may be source of genetic chaos, Temple scientists find

December 12, 2012 by · Leave a Comment 

An international team of scientists, led by researchers from Temple University School of Medicine, has found that a source of mounting genomic chaos, or instability, common to chronic myeloid leukemia (CML) may lie in a pool of leukemia stem cells that are immune to treatment with potent targeted anticancer drugs. They have shown in mice with cancer that even after treatment with the highly effective imatinib (Gleevec), stem cells that become resistant to these drugs – tyrosine kinase inhibitors (TKIs) – may continue to foster DNA damage, potentially leading to disease relapse and a downward spiral to a much more deadly “blast” stage of leukemia.

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Penn study decodes molecular mechanisms underlying stem cell reprogramming

November 16, 2012 by · Leave a Comment 

Fifty years ago, British researcher John Gurdon demonstrated that genetic material from non-reproductive, or somatic, cells could be reprogrammed into an embryonic state when transferred into an egg. In 2006, Kyoto University researcher Shinya Yamanaka expanded on those findings by expressing four proteins in mouse somatic cells to rewind their genetic clocks, converting them into embryonic-like stem cells called induced pluripotent stem cells, or iPS cells.

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Researchers reprogram brain cells to become heart cells

July 8, 2011 by · Leave a Comment 

PHILADELPHIA – For the past decade, researchers have tried to reprogram the identity of all kinds of cell types. Heart cells are one of the most sought-after cells in regenerative medicine because researchers anticipate that they may help to repair injured hearts by replacing lost tissue. Now, researchers at the Perelman School of Medicine at the University of Pennsylvania are the first to demonstrate the direct conversion of a non-heart cell type into a heart cell by RNA transfer. Working on the idea that the signature of a cell is defined by molecules called messenger RNAs (mRNAs), which contain the chemical blueprint for how to make a protein, the investigators changed two different cell types, an astrocyte (a star-shaped brain cell) and a fibroblast (a skin cell), into a heart cell, using mRNAs.

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A new way to make reprogrammed stem cells

April 7, 2011 by · Leave a Comment 

Penn study eliminates the use of transcription factors and increases efficiency 100-fold

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Rare disease reveals new path for creating stem cells

November 21, 2010 by · Leave a Comment 

BOSTON, Mass. (November 21, 2010)—As debilitating as disease can be, sometimes it acts as a teacher.

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