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The Lancet: First report of long-term safety of human embryonic stem cells to treat human disease

October 15, 2014 by · Leave a Comment 

New research published in The Lancet provides the first evidence of the medium-term to long-term safety and tolerability of transplanting human embryonic stem cells (hESCs) in humans.

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Weakness of leukemic stem cells discovered

August 5, 2014 by · Leave a Comment 

Despite improved therapy, only one out of every two adult patients survive acute myeloid leukaemia (AML). The mean survival time for this disease, which predominantly occurs in the elderly, is less than a year for patients over 65 years. It is assumed that leukaemic stem cells, which cannot be completely eliminated during treatment, are the origin of relapse. However, as has been discovered by a team of Frankfurt-based researchers, these cells do have a weakness: In the current edition of the high impact journal “Cancer Research“, they report that the enzyme 5-lipoxygenase (5-LO) plays a significant role in the survival of leukaemic AML stem cells.

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NYSCF scientists one step closer to cell therapy for multiple sclerosis patients

July 24, 2014 by · Leave a Comment 

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute are one step closer to creating a viable cell replacement therapy for multiple sclerosis from a patient’s own cells.

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Novel methods may help stem cells survive transplantation into damaged tissues

July 23, 2014 by · Leave a Comment 

Stem cells offer much promise for treating damaged organs and tissues, but with current transplantation approaches stem cell survival is poor, limiting their effectiveness. New methods are being developed and tested to improve the survival and optimize their therapeutic function after transplantation, as described in a Review article in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

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Embryonic stem cells offer new treatment for multiple sclerosis

June 20, 2014 by · Leave a Comment 

Scientists in the University of Connecticut’s Technology Incubation Program have identified a novel approach to treating multiple sclerosis (MS) using human embryonic stem cells, offering a promising new therapy for more than 2.3 million people suffering from the debilitating disease.

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Critical factor (BRG1) identified for maintaining stem cell pluripotency

February 9, 2014 by · Leave a Comment 

he ability to reprogram adult cells so they return to an undifferentiated, pluripotent state—much like an embryonic stem cell—is enabling the development of promising new cell therapies. Accelerating progress in this field will depend on identifying factors that promote pluripotency, such as the Brg1 protein described in a new study published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

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Cedars-Sinai researchers target cancer stem cells in malignant brain tumors

January 6, 2014 by · Leave a Comment 

Researchers at the Cedars-Sinai Maxine Dunitz Neurosurgical Institute and Department of Neurosurgery identified immune system targets on cancer stem cells – cells from which malignant brain tumors are believed to originate and regenerate – and created an experimental vaccine to attack them.

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Human neural stem cells could meet the clinical problem of critical limb ischemia

November 26, 2013 by · Leave a Comment 

New research has shown human neural stem cells could improve blood flow in critical limb ischemia through the growth of new vessels. Critical limb ischemia (CLI) is a disease that severely obstructs arteries and reduces the blood flow to legs and feet. CLI remains an unmet clinical problem and with an ageing population and the rise in type II diabetes, the incidence of CLI is expected to increase.

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Heart’s own stem cells offer hope for new treatment of heart failure

August 17, 2013 by · Leave a Comment 

Researchers at King’s College London have for the first time highlighted the natural regenerative capacity of a group of stem cells that reside in the heart. This new study shows that these cells are responsible for repairing and regenerating muscle tissue damaged by a heart attack which leads to heart failure.

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Spine function improves following cell replacement therapy with fetal human stem cells

May 28, 2013 by · Leave a Comment 

Human foetal stem cell grafts improve both motor and sensory functions in rats suffering from a spinal cord injury, according to research published this week in BioMed Central’s open access journal Stem Cell Research and Therapy. This cell replacement therapy also improves the structural integrity of the spine, providing a functional relay through the injury site. The research gives hope for the treatment of spinal cord injuries in humans.

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