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New way to repair nerves: Using exosomes to hijack cell-to-cell communication

September 15, 2015 by · Leave a Comment 

Regenerative medicine using stem cells is an increasingly promising approach to treat many types of injury. Transplanted stem cells can differentiate into just about any other kind of cell, including neurons to potentially reconnect a severed spinal cord and repair paralysis.

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NYSCF Global Stem Cell ArrayTM brings precision medicine one step closer to the clinic

August 3, 2015 by · Leave a Comment 

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells. This unique platform, the NYSCF Global Stem Cell ArrayTM, for the first time gives researchers the scale to look at diverse populations to better understand the underlying causes of disease and create new individually tailored treatments, enabling precision medicine in patient care.

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Blood stem cells in a rush — velocity determines quality

July 11, 2015 by · Leave a Comment 

For the first time, the research group of Prof. Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic impact on the fitness of human blood stem cells. In the study, the shortened G1 phase resulted in much improved continuous production of mature blood cells from stem cells over a prolonged period of time. It is imaginable that the stem cell function can also be increased in the human body in the future by an acceleration of cell cycle transition kinetic. The work has now been published in the Journal of Experimental Medicine(DOI:10.1084/jem.20150308).

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Prenatal stem cell treatment improves mobility issues caused by spina bifida

April 30, 2015 by · Leave a Comment 

The lower-limb paralysis associated with spina bifida may be effectively treated before birth by combining a unique stem cell therapy with surgery, new research from UC Davis Health System has found.

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Stem cell injection may soon reverse vision loss due to age-related macular degeneration

April 16, 2015 by · Leave a Comment 

An injection of stem cells into the eye may soon slow or reverse the effects of early-stage age-related macular degeneration, according to new research from scientists at Cedars-Sinai. Currently, there is no treatment that slows the progression of the disease, which is the leading cause of vision loss in people over 65.

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First stem cell-based approach to treat type 2 diabetes effective in mice

March 22, 2015 by · Leave a Comment 

A combination of human stem cell transplantation and antidiabetic drugs proved to be highly effective at improving body weight and glucose metabolism in a mouse model of type 2 diabetes. The findings, published March 19th by Stem Cell Reports, could set the stage for clinical trials to test the first stem cell-based approach for insulin replacement in patients with type 2 diabetes.

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Super-resolution microscopes reveal the link between genome packaging and cell pluripotency

March 13, 2015 by · Leave a Comment 

In 1953 Watson and Crick first published the discovery of the double helix structure of the DNA. They were able to visualize the DNA structure by means of X-Ray diffraction. Techniques, such as electron microscopy, allowed scientists to identify nucleosomes, the first and most basic level of chromosome organisation. Until now it was known that our DNA is packaged by regular repeating units of those nucleosomes throughout the genome giving rise to chromatin. However, due to the lack of suitable techniques and instruments, the chromatin organisation inside a cell nucleus could not be observed in a non-invasive way with the sufficient resolution. Now, for the first time, a group of scientists at the CRG and ICFO in Barcelona, have been able to visualise and even count the smallest units which, packaged together, form our genome. This study was possible thanks to the use of super-resolution microscopy, a new cutting-edge optical technique that received the Nobel Prize in Chemistry in 2014. In combination with innovative quantitative approaches and numerical simulations, they were also able to define the genome architecture at the nano-scale. Most importantly, they found that the nucleosomes are assembled in irregular groups across the chromatin and nucleosome-free-DNA regions separate these groups.

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Human neural stem cells restore cognitive functions impaired by chemotherapy

February 16, 2015 by · Leave a Comment 

Human neural stem cell treatments are showing promise for reversing learning and memory deficits after chemotherapy, according to UC Irvine researchers.

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Researchers advance the science behind treating patients with corneal blindness

January 29, 2015 by · Leave a Comment 

Researchers in the Cedars-Sinai Board of Governors Regenerative Medicine Institute have devised a novel way to generate transplantable corneal stem cells that may eventually benefit patients suffering from life-altering forms of blindness.

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Stem cells derived from amniotic tissues have immunosuppressive properties

January 19, 2015 by · Leave a Comment 

Stem cells derived from human amnion have for some time been considered promising for cell therapies because of their ease of access, ability to differentiate, and absence of ethical issues. Now, a Japanese research team has found that stem cells derived from human female amnion also have immunosuppressive activity and that the addition of antibodies to specific factors can enhance their immunosuppressive potential.

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