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Investigators create complex kidney structures from human stem cells derived from adults

October 23, 2015 by · Leave a Comment 

Investigators at Brigham and Women’s Hospital (BWH) and the Harvard Stem Cell Institute (HSCI) have established a highly efficient method for making kidney structures from stem cells that are derived from skin taken from patients. The kidney structures formed could be used to study abnormalities of kidney development, chronic kidney disease, the effects of toxic drugs, and be incorporated into bioengineered devices to treat patients with acute and chronic kidney injury. In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient’s own cells. These results were published in Nature Biotechnology this week.

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Sleep deprivation affects stem cells, reducing transplant efficiency, study finds

October 14, 2015 by · Leave a Comment 

Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine.

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Johns Hopkins biologist leads research shedding light on stem cells

October 8, 2015 by · Leave a Comment 

A Johns Hopkins University biologist has led a research team reporting progress in understanding the mysterious shape-shifting ways of stem cells, which have vast potential for medical research and disease treatment.

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Filling a void in stem cell therapy

September 15, 2015 by · Leave a Comment 

Stem cell therapies are often limited by low survival of transplanted stem cells and the lack of precise control over their differentiation into the terminal cell types needed to repair or replace injured tissues. Now, a team led by Wyss Institute Core Faculty member David Mooney, Ph.D., has developed a new strategy – embedding stem cells into porous, transplantable hydrogels – that has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation.

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Researchers mimic viral infection in colon cancer stem cells

August 27, 2015 by · Leave a Comment 

Researchers targeting colorectal cancer stem cells – the root cause of disease, resistance to treatment and relapse – have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

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Study provides hope for some human stem cell therapies

August 21, 2015 by · Leave a Comment 

An international team of scientists headed by biologists at UC San Diego has discovered that an important class of stem cells known as human “induced pluripotent stem cells,” or iPSCs, which are derived from an individual’s own cells, can be differentiated into various types of functional cells with different fates of immune rejection.

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Programming adult stem cells to treat muscular dystrophy and more by mimicking nature

July 22, 2015 by · Leave a Comment 

Stem cells hold great potential for addressing a variety of conditions from spinal cord injuries to cancer, but they can be difficult to control. Scientists are now reporting in the journal ACS Nano a new way to mimic the body’s natural approach to programming these cells. Using this method, they successfully directed adult stem cells to turn specifically into muscle, which could potentially help treat patients with muscular dystrophy.

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T-cell receptor therapy achieves encouraging clinical responses in multiple myeloma

July 21, 2015 by · Leave a Comment 

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person’s own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT). This time, researchers modified T cells to attack cancer cells expressing NY-ESO-1, an antigen found in nearly 60 percent of multiple myelomas and previously shown to be associated with tumor growth and poor prognosis.

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Diabetic blindness: UVA IDs best source of stem cells to block vision loss

June 25, 2015 by · Leave a Comment 

University of Virginia School of Medicine researchers have taken a significant step forward in their efforts to use stem cells to block vision loss caused by diabetic retinopathy, a condition that affects millions of people with diabetes. The researchers have evaluated the best potential sources for adult stem cells to be used for that purpose, determining that cells taken from donors who do not suffer diabetes likely will be more effective than cells taken from patients’ own bodies.

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Scientists find way to disrupt brain tumor stem cells

June 12, 2015 by · Leave a Comment 

ome brain tumors are notoriously difficult to treat. Whether surgically removed, zapped by radiation or infiltrated by chemotherapy drugs, they find a way to return.

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