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Scientists sequence genome of worm that can regrow body parts, seeking stem cell insights

September 22, 2015 by · Leave a Comment 

Tourists spending a recuperative holiday on the Italian coast may be envious of the regenerative abilities of locally found flatworm Macrostomum lignano. Named for its discovery near the Italian beach town of Lignano Sabbiadoro, this tiny worm can regenerate almost its whole body following an injury, and researchers have long been trying to understand how it’s able to pull off this trick.

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Switching mouse neural stem cells to a primate-like behavior

August 8, 2015 by · Leave a Comment 

When the right gene is expressed in the right manner in the right population of stem cells, the developing mouse brain can exhibit primate-like features. In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells. This altered the behavior of these cells to one that is akin to that of progenitors in the developing primate neocortex. Consequently, the mouse progenitors generated more neurons – a prerequisite for a bigger brain.

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Stem cells move one step closer to cure for genetic diseases

July 16, 2015 by · Leave a Comment 

Stem cells are key for the continual renewal of tissues in our bodies. As such, manipulating stem cells also holds much promise for biomedicine if their regenerative capacity can be harnessed. However, understanding how stem cells govern normal tissue renewal is a field still in its infancy.

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Blood stem cells in a rush — velocity determines quality

July 11, 2015 by · Leave a Comment 

For the first time, the research group of Prof. Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic impact on the fitness of human blood stem cells. In the study, the shortened G1 phase resulted in much improved continuous production of mature blood cells from stem cells over a prolonged period of time. It is imaginable that the stem cell function can also be increased in the human body in the future by an acceleration of cell cycle transition kinetic. The work has now been published in the Journal of Experimental Medicine(DOI:10.1084/jem.20150308).

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Researchers uncover epigenetic switches that turn stem cells into blood vessel cells

June 26, 2015 by · Leave a Comment 

Researchers at the University of Illinois at Chicago have identified a molecular mechanism that directs embryonic stem cells to mature into endothelial cells — the specialized cells that form blood vessels. Understanding the processes initiated by this mechanism could help scientists more efficiently convert stem cells into endothelial cells for use in tissue repair, or for engineering blood vessels to bypass blockages in the heart.

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Master orchestrator of the genome is discovered, UB stem cell scientists report

May 8, 2015 by · Leave a Comment 

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Stem-cell-based therapy promising for treatment of breast cancer metastases in the brain

April 26, 2015 by · Leave a Comment 

Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital (MGH) have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study published online in the journal Brain also describes a strategy of preventing the potential negative consequences of stem cell therapy.

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UAlberta research reveals new possibilities for islet and stem cell transplantation

April 23, 2015 by · Leave a Comment 

James Shapiro, one of the world’s leading experts in emerging treatments of diabetes, can’t help but be excited about his latest research. The results he says, could soon mark a new standard for treatment–not only in diabetes, but in several other diseases as well.

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Stem cell disease model clarifies bone cancer trigger

April 10, 2015 by · Leave a Comment 

Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers, where the survival rate has not improved in 40 years despite treatment advances.

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Stem cells help researchers peg rabies resistance

March 19, 2015 by · Leave a Comment 

Researchers at Texas A&M AgriLife Research have developed a new technology to determine sensitivity or resistance to rabies virus.

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