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Certain donors with high T cell counts make better match for stem-cell transplant patients

June 9, 2015 by · Leave a Comment 

Using a simple blood test to measure the T lymphocyte count in donors for stem cell transplants may help identify the best match for patients in need of an allogeneic stem cell transplant, suggests a new study in the Journal of Clinical Oncology from researchers at the Abramson Cancer Center (ACC) of the University of Pennsylvania. Typically, matched siblings have been preferred over unrelated donors. This study shows that older patients who received stem cells from younger, unrelated donors with higher numbers of so-called killer T cells (CD8 cells) had significantly reduced risk of disease relapse and improved survival compared to those who received stem-cells from donors with low numbers of CD8 cells, including older matched siblings.

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Promising use of nanodiamonds in delivering cancer drug to kill cancer stem cells

January 26, 2015 by · Leave a Comment 

A study led by the National University of Singapore (NUS) found that attaching chemotherapy drug Epirubicin to nanodiamonds effectively eliminates chemoresistant cancer stem cells. The findings were first published online in ACS Nano, the official journal of the American Chemical Society, in December 2014.

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Blood stem cells age at the unexpected flip of a molecular switch

October 20, 2013 by · Leave a Comment 

Scientists report in Nature they have found a novel and unexpected molecular switch that could become a key to slowing some of the ravages of getting older as it prompts blood stem cells to age.

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