Sleep deprivation affects stem cells, reducing transplant efficiency, study finds

October 14, 2015 by · Leave a Comment 

Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine.

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Discovery offers hope for treating leukemia relapse post-transplant

September 11, 2015 by · Leave a Comment 

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.

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Depletion of naive T cells from stem cell grafts limits chronic graft-versus host disease

June 9, 2015 by · Leave a Comment 

Stem cell transplantation is used to treat hematologic malignancies, such as leukemia. Patients that receive donor cells are at risk of developing graft-versus host disease (GVHD). This potentially fatal complication results when naive T cells generated from the graft promote an immune response that attacks the recipient’s tissues. Prophylactic treatment with immunosuppressive drugs is currently used to limit GVHD but does not reliably prevent disease. In mouse models, depletion of naive T cells from the stem cell graft prior to transplant reduces the occurrence and severity of GVHD. A new study in the Journal of Clinical Investigation evaluates GVHD in a small set of patients with leukemia that received stem cell grafts that had been depleted of naïve T cells prior to transplantation. Marie Bleakley and colleagues at the Fred Hutchinson Cancer Research Center showed that reduction of naïve T cells in the donor graft markedly reduces the occurrence of chronic GVHD disease in patients. There was no reduction in the overall rate of acute GVHD occurrence in these patients. However, acute GVHD in these recipients was generally responsive to corticosteroid therapy. The results of this study support depletion of naïve T cells from stem cell grafts prior to transplantation as a potential treatment option to limit chronic GVHD in patients.

Novel drug regimen can improve stem cell transplantation outcomes

December 8, 2013 by · Leave a Comment 

Adding bortezomib (Velcade) to standard preventive therapy for graft-versus-host-disease (GVHD) results in improved outcomes for patients receiving stem-cell transplants from mismatched and unrelated donors, according to researchers from Dana-Farber Cancer Institute.

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New technique provides human embryonic stem cells for personalized medicine

May 16, 2013 by · Leave a Comment 

Somatic cell nuclear transfer (SCNT) is a technique in which the nucleus of a donor cell is transferred to an egg cell whose nucleus has been removed, generating embryos that are almost an identical genetic match to the donor individual. For the first time, a team of scientists has used SCNT to produce human embryonic stem cells (hESCs). This milestone, published by Cell Press May 15th in the journal Cell, opens up new avenues for using stem cells to understand patient-specific causes of disease and for developing personalized therapies.

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Stem cells show promise for treating infertility in cancer patients

November 1, 2012 by · Leave a Comment 

A promising stem-cell-based approach for treating infertility has been successfully demonstrated in non-human primates, as reported in a study published by Cell Press in the November issue of the journal Cell Stem Cell. The preclinical study represents an important milestone for translating this strategy to the clinic, particularly for cancer survivors who have been rendered infertile by chemotherapy they received before reaching sexual maturity.

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Moffitt researcher says no survival advantage with peripheral blood stem cells versus bone marrow

October 22, 2012 by · Leave a Comment 

Claudio Anasetti, M.D., chair of the Department of Blood & Marrow Transplant at Moffitt Cancer Center, and colleagues from 47 research sites in the Blood and Marrow Transplant Clinical Trials Network conducted a two-year clinical trial comparing two-year survival probabilities for patients transplanted with peripheral blood stem cells or bone marrow stem cells from unrelated donors. The goal was to determine whether graft source, peripheral blood stem cells or bone marrow, affects outcomes in unrelated donor transplants for patients with leukemia or other hematologic malignancies.

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Deadly complication of stem cell transplants reduced in mice

September 27, 2012 by · Leave a Comment 

Studying leukemia in mice, researchers at Washington University School of Medicine in St. Louis have reduced a life-threatening complication of stem cell transplants, the only curative treatment when leukemia returns.

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Neurologic improvement detected in rats receiving stem cell transplant

February 10, 2012 by · Leave a Comment 

In a study to be presented today at the Society for Maternal-Fetal Medicine’s annual meeting, The Pregnancy Meeting ™, in Dallas, Texas, researchers will report that early transplantation of human placenta-derived mesenchymal stem cells into the lateral ventricles of neonatal rats with birth-related brain damage is possible, and that the donor cells can survive and migrate in the recipient’s brain. The study was designed to have the rat’s brain damage mimic brain injury in infants with very low birth weight.

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Adult stem cells take root in livers and repair damage

May 11, 2011 by · Leave a Comment 

Johns Hopkins researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.

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