New method for testing iPSC differentiation potential could lead to safer and more potent treatments

September 22, 2015 by · Leave a Comment 

The discovery of human induced pluripotent stem cells (iPSCs) in 2006 completely revolutionized the field of stem cell biology. iPSC lines have become powerful tools that can be used to study human embryonic development, as model systems for human diseases. They are also helpful as a renewable source for regenerative medicine, where these cells are expected to play a key role in the development of many regenerative medicine therapies.

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Discovery offers hope for treating leukemia relapse post-transplant

September 11, 2015 by · Leave a Comment 

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.

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NYSCF Global Stem Cell ArrayTM brings precision medicine one step closer to the clinic

August 3, 2015 by · Leave a Comment 

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells. This unique platform, the NYSCF Global Stem Cell ArrayTM, for the first time gives researchers the scale to look at diverse populations to better understand the underlying causes of disease and create new individually tailored treatments, enabling precision medicine in patient care.

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Vital step in stem cell growth revealed

May 3, 2015 by · Leave a Comment 

Stem cells, which have the potential to turn into any kind of cell, offer the tantalizing possibility of generating new tissues for organ replacements, stroke victims and patients of many other diseases. Now, scientists at the Salk Institute have uncovered details about stem cell growth that could help improve regenerative therapies.

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Is stem cell therapy less effective in older patients with chronic diseases?

January 13, 2015 by · Leave a Comment 

A promising new therapeutic approach to treat a variety of diseases involves taking a patient’s own cells, turning them into stem cells, and then deriving targeted cell types such as muscle or nerve cells to return to the patient to repair damaged tissues and organs. But the clinical effectiveness of these stem cells has only been modest, which may be due to the advanced age of the patients or the effects of chronic diseases such as diabetes and cardiovascular disease, according to a probing Review article published inBioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers . The article is available on theBioResearch Open Access website.

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Researchers recreate stem cells from deceased patients to study present-day illnesses

December 2, 2014 by · Leave a Comment 

Research scientists have developed a novel method to re-create brain and intestinal stem cells from patients who died decades ago, using DNA from stored blood samples to study the potential causes of debilitating illnesses such as inflammatory bowel disease.

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Nail stem cells prove more versatile than press ons

November 21, 2014 by · Leave a Comment 

There are plenty of body parts that don’t grow back when you lose them. Nails are an exception, and a new study published in the Proceedings of the National Academy of Sciences (PNAS) reveals some of the reasons why.

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New genomic editing methods produce better disease models from patient-derived iPSCs

September 8, 2014 by · Leave a Comment 

Highly valuable for modeling human diseases and discovering novel drugs and cell-based therapies, induced pluripotent stem cells (iPSCs) are created by reprogramming an adult cell from a patient to obtain patient-specific stem cells. Due to genetic variation, however, iPSCs may differ from a patient’s diseased cells, and researchers are now applying new and emerging genomic editing tools to human disease modeling, as described in a comprehensive Review article published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Development website until September 30, 2014.

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New tool aids stem cell engineering for medical research

August 29, 2014 by · 1 Comment 

A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform that uses network biology methods to aid stem cell engineering. Details of CellNet and its application to stem cell engineering are described in two back-to-back papers in the journal Cell.

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USC Stem Cell scientists lay a TRAP for disease

July 13, 2014 by · Leave a Comment 

USC Stem Cell scientists have set a “mouse TRAP” to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigation. Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs.

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