Variations in cell programs control cancer and normal stem cells

September 3, 2015 by · Leave a Comment 

In the breast, cancer stem cells and normal stem cells can arise from different cell types but tap into distinct yet related stem cell programs, according to Whitehead Institute researchers. The differences between these stem cell programs may be significant enough to be exploited by future therapeutics.

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Certain donors with high T cell counts make better match for stem-cell transplant patients

June 9, 2015 by · Leave a Comment 

Using a simple blood test to measure the T lymphocyte count in donors for stem cell transplants may help identify the best match for patients in need of an allogeneic stem cell transplant, suggests a new study in the Journal of Clinical Oncology from researchers at the Abramson Cancer Center (ACC) of the University of Pennsylvania. Typically, matched siblings have been preferred over unrelated donors. This study shows that older patients who received stem cells from younger, unrelated donors with higher numbers of so-called killer T cells (CD8 cells) had significantly reduced risk of disease relapse and improved survival compared to those who received stem-cells from donors with low numbers of CD8 cells, including older matched siblings.

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RegMedNet shines light on use of stem cells as a potential Huntington’s disease treatment

April 26, 2015 by · Leave a Comment 

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG triplet expansion in the Huntington gene, which causes progressive neuropsychiatric and motor dysfunction and leads to death. There is currently no cure for HD – treatment is strictly palliative.

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Delivering stem cells into heart muscle may enhance cardiac repair and reverse injury

November 20, 2014 by · Leave a Comment 

Delivering stem cell factor directly into damaged heart muscle after a heart attack may help repair and regenerate injured tissue, according to a study led by researchers from Icahn School of Medicine at Mount Sinai presented November 18 at the American Heart Association Scientific Sessions 2014 in Chicago, IL.

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Rutgers Chemistry’s Ki-Bum Lee patents technology to advance stem cell therapeutics

November 13, 2014 by · Leave a Comment 

Rutgers University Chemistry Associate Professor Ki-Bum Lee has developed patent-pending technology that may overcome one of the critical barriers to harnessing the full therapeutic potential of stem cells.

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Biological fat with a sugar attached essential to maintaining the brain’s supply of stem cells

November 4, 2014 by · Leave a Comment 

Fat and sugar aren’t usually considered healthy staples, but scientists have found that a biological fat with a sugar attached is essential for maintaining the brain’s store of stem cells.

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Growing a blood vessel in a week

October 24, 2014 by · Leave a Comment 

Just three years ago, a patient at Sahlgrenska University Hospital received a blood vessel transplant grown from her own stem cells.

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The Lancet: First report of long-term safety of human embryonic stem cells to treat human disease

October 15, 2014 by · Leave a Comment 

New research published in The Lancet provides the first evidence of the medium-term to long-term safety and tolerability of transplanting human embryonic stem cells (hESCs) in humans.

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A non-toxic strategy to treat leukemia

September 12, 2014 by · Leave a Comment 

A study comparing how blood stem cells and leukemia cells consume nutrients found that cancer cells are far less tolerant to shifts in their energy supply than their normal counterparts. The results suggest that there could be ways to target leukemia metabolism so that cancer cells die but other cell types are undisturbed.

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Scientists identify rare stem cells that hold potential for infertility treatments

September 6, 2014 by · Leave a Comment 

Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells — and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests.

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