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Sustained remission of multiple myeloma achieved after personalized cellular therapy

September 10, 2015 by · Leave a Comment 

A multiple myeloma patient whose cancer had stopped responding after nine different treatment regimens experienced a complete remission after receiving an investigational personalized cellular therapy known as CTL019 developed by a team at the University of Pennsylvania. The investigational treatment was combined with chemotherapy and an autologous stem cell transplant – a new strategy designed to target and kill the cells that give rise to myeloma cells.

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Researchers mimic viral infection in colon cancer stem cells

August 27, 2015 by · Leave a Comment 

Researchers targeting colorectal cancer stem cells – the root cause of disease, resistance to treatment and relapse – have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

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NYSCF Global Stem Cell ArrayTM brings precision medicine one step closer to the clinic

August 3, 2015 by · Leave a Comment 

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells. This unique platform, the NYSCF Global Stem Cell ArrayTM, for the first time gives researchers the scale to look at diverse populations to better understand the underlying causes of disease and create new individually tailored treatments, enabling precision medicine in patient care.

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T-cell receptor therapy achieves encouraging clinical responses in multiple myeloma

July 21, 2015 by · Leave a Comment 

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person’s own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT). This time, researchers modified T cells to attack cancer cells expressing NY-ESO-1, an antigen found in nearly 60 percent of multiple myelomas and previously shown to be associated with tumor growth and poor prognosis.

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UTHealth research: Autologous stem cell therapy helpful in traumatic brain injury

June 8, 2015 by · Leave a Comment 

The use of cell therapy after traumatic brain injury (TBI) in children can reduce the amount of therapeutic interventions needed to treat the patient, as well as the amount of time the child spends in neurointensive care, according to research by The University of Texas Health Science Center at Houston (UTHealth) Medical School.

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Infusions of donor bone marrow cells help children with inherited skin blistering

May 27, 2015 by · 1 Comment 

Promising results from a trial of a new stem-cell based therapy for a rare and debilitating skin condition have been published in the Journal of Investigative Dermatology. The therapy, involving infusions of stem cells, was found to provide pain relief and to reduce the severity of this skin condition for which no cure currently exists.

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Drugs stimulate body’s own stem cells to replace brain cells lost in multiple sclerosis

April 21, 2015 by · Leave a Comment 

A pair of topical medicines already alleviating skin conditions each may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis.

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First stem cell-based approach to treat type 2 diabetes effective in mice

March 22, 2015 by · Leave a Comment 

A combination of human stem cell transplantation and antidiabetic drugs proved to be highly effective at improving body weight and glucose metabolism in a mouse model of type 2 diabetes. The findings, published March 19th by Stem Cell Reports, could set the stage for clinical trials to test the first stem cell-based approach for insulin replacement in patients with type 2 diabetes.

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Patient stem cells used to make dementia-in-a-dish; help identify new treatment strategy

December 31, 2014 by · Leave a Comment 

Belgian researchers have identified a new strategy for treating an inherited form of dementia after attempting to turn stem cells derived from patients into the neurons most affected by the disease. In patient-derived stem cells carrying a mutation predisposing them to frontotemporal dementia, which accounts for about half of dementia cases before the age of 60, the scientists found a targetable defect that prevents normal neurodevelopment. These stem cells partially return to normal when the defect is corrected.

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Reprogramming stem cells may prevent cancer after radiation

December 31, 2014 by · Leave a Comment 

The body has evolved ways to get rid of faulty stem cells. A University of Colorado Cancer Center study published today in the journal Stem Cells shows that one of these ways is a “program” that makes stem cells damaged by radiation differentiate into other cells that can no longer survive forever. Radiation makes a stem cell lose its “stemness.” That makes sense: you don’t want damaged stem cells sticking around to crank out damaged cells.

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