A new genome editing method brings the possibility of gene therapies closer to reality

July 11, 2014 by · Leave a Comment 

Researchers from Salk Institute for Biological Studies, BGI, and other institutes for the first time evaluated the safety and reliability of the existing targeted gene correction technologies, and successfully developed a new method, TALEN-HDAdV, which could significantly increased gene-correction efficiency in human induced pluripotent stem cell (hiPSC). This study published online in Cell Stell Cell provides an important theoretical foundation for stem cell-based gene therapy.

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Study finds long-term survival of human neural stem cells transplanted into primate brain

April 24, 2014 by · Leave a Comment 

A team of researchers in Korea who transplanted human neural stem cells (hNSCs) into the brains of nonhuman primates and assessed cell survival and differentiation after 22 and 24 months found that the hNSCs had differentiated into neurons at 24 months and did not cause tumors.

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Diabetes distresses bone marrow stem cells by damaging their microenvironment

February 2, 2013 by · Leave a Comment 

New research has shown the presence of a disease affecting small blood vessels, known as microangiopathy, in the bone marrow of diabetic patients. While it is well known that microangiopathy is the cause of renal damage, blindness and heart attacks in patients with diabetes, this is the first time that a reduction of the smallest blood vessels has been shown in bone marrow, the tissue contained inside the bones and the main source of stem cells.

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New patient-friendly way to make stem cells for fight against heart disease

December 3, 2012 by · Leave a Comment 

Scientists – funded by the British Heart Foundation (BHF), Medical Research Council (MRC) and Wellcome Trust – have today published a patient-friendly and efficient way to make stem cells out of blood, increasing the hope that scientists could one day use stem cells made from patients’ own cells to treat cardiovascular disease (1).

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Myelodysplastic syndromes (MDS) linked to abnormal stem cells

July 2, 2012 by · 3 Comments 

Researchers at Albert Einstein College of Medicine of Yeshiva University have found that abnormal bone marrow stem cells drive the development of myelodysplastic syndromes (MDS), serious blood diseases that are common among the elderly and that can progress to acute leukemia. The findings could lead to targeted therapies against MDS and prevent MDS-related cancers. The study is published today in the online edition of the journal Blood.

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Stem cells can beat back diabetes: Transplant of cells can restore insulin production

June 28, 2012 by · Leave a Comment 

University of British Columbia scientists, in collaboration with an industry partner, have successfully reversed diabetes in mice using stem cells, paving the way for a breakthrough treatment for a disease that affects nearly one in four Canadians.

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Stem cells from cord blood could help repair damaged heart muscle

October 13, 2011 by · Leave a Comment 

At least 20 million people survive heart attacks and strokes every year, according to World Health Organisation estimates, but many have poor life expectancy and require continual costly clinical care. The use of patient’s own stem cells may repair heart attacks, although their benefit may be limited due to scarce availability and ageing. The researchers have found heart muscle-like cells grown using stem cells from human umbilical cord blood could help repair heart muscle cells damaged by a heart attack.

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Stem cell study could pave the way to treatment for age-related muscle wasting

May 17, 2011 by · Leave a Comment 

A team led by developmental biologist Professor Christophe Marcelle has nailed the mechanism that causes stem cells in the embryo to differentiate into specialised cells that form the skeletal muscles of animals’ bodies. The scientists published their results in the British journal Nature on Monday (May 16).

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