- Identifying the source of stem cells
- Scientists generate first human stomach tissue in lab with stem cells
- A mechanism that allows a differentiated cell to reactivate as a stem cell revealed
- Scientists engineer toxin-secreting stem cells to treat brain tumors
- Growing a blood vessel in a week
- Human skin cells reprogrammed directly into brain cells
- New insight that ‘mega’ cells control the growth of blood-producing cells
- Lab-developed intestinal organoids form mature human tissue in mice
When most animals begin life, cells immediately begin accepting assignments to become a head, tail or a vital organ. However, mammals, including humans, are special. The cells of mammalian embryos get to make a different first choice – to become the protective placenta or to commit to forming the baby.
Scientists used pluripotent stem cells to generate functional, three-dimensional human stomach tissue in a laboratory – creating an unprecedented tool for researching the development and diseases of an organ central to several public health crises, ranging from cancer to diabetes.
One kind of stem cell, those referred to as ‘facultative’, form part—together with other cells—of tissues and organs. There is apparently nothing that differentiates these cells from the others. However, they have a very special characteristic, namely they retain the capacity to become stem cells again. This phenomenon is something that happens in the liver, an organ that hosts cells that stimulate tissue growth, thus allowing the regeneration of the organ in the case of a transplant. Knowledge of the underlying mechanism that allows these cells to retain this capacity is a key issue in regenerative medicine.
Harvard Stem Cell Institute scientists at Massachusetts General Hospital have devised a new way to use stem cells in the fight against brain cancer. A team led by neuroscientist Khalid Shah, MS, PhD, who recently demonstrated the value of stem cells loaded with cancer-killing herpes viruses, now has a way to genetically engineer stem cells so that they can produce and secrete tumor-killing toxins.
Just three years ago, a patient at Sahlgrenska University Hospital received a blood vessel transplant grown from her own stem cells.
Scientists have described a way to convert human skin cells directly into a specific type of brain cell affected by Huntington’s disease, an ultimately fatal neurodegenerative disorder. Unlike other techniques that turn one cell type into another, this new process does not pass through a stem cell phase, avoiding the production of multiple cell types, the study’s authors report.
Cancer TreatmentExperts from CNIO discover shining cells responsible for developing tumors Scientists identify rare stem cells that hold potential for infertility treatments The young sperm, poised for greatness Cancer stem cells under the microscope at Albert Einstein College of Medicine symposium
Organs & BonesA mechanism that allows a differentiated cell to reactivate as a stem cell revealed Growing a blood vessel in a week
Just three years ago, a patient at Sahlgrenska University Hospital received a blood vessel transplant grown from her own stem cells. Read More →Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg NYU Langone scientists identify key factor that maintains stem cell identity