- Blocking differentiation is enough to give cells ‘stemness’
- Investigators create complex kidney structures from human stem cells derived from adults
- A step forward in obtaining blood stem cells in laboratory
- Sleep deprivation affects stem cells, reducing transplant efficiency, study finds
- Johns Hopkins biologist leads research shedding light on stem cells
- Restoring vision with stem cells
- A snapshot of stem cell expression
- Sticky gel helps stem cells heal rat hearts
Stem Cell TutorialPotential uses of human stem cells and the obstacles that must be overcome A deeper look at induced pluripotent stem cells Comparing similarities and differences between embryonic and adult stem cells Describing adult stem cells What are embryonic stem cells and how are they grown? What are the unique properties of stem cells that make them so special?
Though immune therapy and regenerative medicine are promising areas of research for future medical therapies, they are limited today by the difficulty of creating stem cells, and scientists around the world are searching for ways to create somatic stem cells in the easiest way possible. Now, a collaboration between the RIKEN Center for Integrative Medical Science (IMS) and other institutions in Japan and Europe have found that in immune cells, simply blocking a transcription factor that leads to differentiation is sufficient to keep cells in a multipotent stem cell-like state where they can continue to proliferate and can later differentiate into various cell types.
Investigators at Brigham and Women’s Hospital (BWH) and the Harvard Stem Cell Institute (HSCI) have established a highly efficient method for making kidney structures from stem cells that are derived from skin taken from patients. The kidney structures formed could be used to study abnormalities of kidney development, chronic kidney disease, the effects of toxic drugs, and be incorporated into bioengineered devices to treat patients with acute and chronic kidney injury. In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient’s own cells. These results were published in Nature Biotechnology this week.
An international study led by researchers from IMIM (Hospital del Mar Medical Research Institute) published in the journal Nature Communications has revealed that the intensity or efficiency of the activation of a protein called Notch, which is involved in the different phases of embryonic development, determines the fate of cells, i.e. if cells will form the aorta artery or blood (hematopoietic) stem cells. For artery cells, many Notch molecules need to be activated, whereas for hematopoietic cells many fewer are needed.
Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine.
A Johns Hopkins University biologist has led a research team reporting progress in understanding the mysterious shape-shifting ways of stem cells, which have vast potential for medical research and disease treatment.
Age-related macular degeneration (AMRD) could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, thanks to findings published today by Professor Gilbert Bernier of the University of Montreal and its affiliated Maisonneuve-Rosemont Hospital. ARMD is a common eye problem caused by the loss of cones. Bernier’s team has developed a highly effective in vitro technique for producing light sensitive retina cells from human embryonic stem cells. “Our method has the capacity to differentiate 80% of the stem cells into pure cones,” Professor Gilbert explained. “Within 45 days, the cones that we allowed to grow towards confluence spontaneously formed organised retinal tissue that was 150 microns thick. This has never been achieved before.”
Cancer TreatmentBlocking differentiation is enough to give cells ‘stemness’ Investigators create complex kidney structures from human stem cells derived from adults A step forward in obtaining blood stem cells in laboratory Sleep deprivation affects stem cells, reducing transplant efficiency, study finds
Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine. Read More →