- New insight that ‘mega’ cells control the growth of blood-producing cells
- Lab-developed intestinal organoids form mature human tissue in mice
- Pitt/McGowan Institute team discovers stem cells in the esophagus
- Cryptic clues drive new theory of bowel cancer development
- Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg
- Autophagy helps fast track stem cell activation
- The Lancet: First report of long-term safety of human embryonic stem cells to treat human disease
- Spinal cord injury victims may benefit from stem cell transplantation studies
While megakaryocytes are best known for producing platelets that heal wounds, these “mega” cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. In fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marrow. The Stowers study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes).
Researchers have successfully transplanted “organoids” of functioning human intestinal tissue grown from pluripotent stem cells in a lab dish into mice – creating an unprecedented model for studying diseases of the intestine.
Despite previous indications to the contrary, the esophagus does have its own pool of stem cells, said researchers from the University of Pittsburgh School of Medicine in an animal study published online today in Cell Reports. The findings could lead to new insights into the development and treatment of esophageal cancer and the precancerous condition known as Barrett’s esophagus.
Melbourne researchers have challenged conventional thinking on how the bowel lining develops and, in the process, suggested a new mechanism for how bowel cancer starts.
A Mount Sinai-led research team has discovered a new kind of stem cell that can become either a liver cell or a cell that lines liver blood vessels, according to a study published today in the journal Stem Cell Reports. The existence of such a cell type contradicts current theory on how organs arise from cell layers in the embryo, and may hold clues to origins of, and future treatment for, liver cancer.
Researchers from Stanford University School of Medicine have discovered a link between a protective mechanism used by cells and the activation of muscle stem cells. Cells use autophagy to recycle cellular “building blocks” and generate energy during times of nutrient deprivation. The scientists report in The EMBO Journal that when this protective mechanism is operational it also seems to assist in the activation of stem cells.