- Transplanted human umbilical cord blood cells improved heart function in rat model of MI
- Alzheimer’s in a dish
- Penn researchers show nuclear stiffness keeps stem cells and cancer cells in place
- Researchers generate new neurons in brains, spinal cords of living adult mammals
- Like mom or dad? Some cells randomly express one parent’s version of a gene over the other
- Turning back the clock on aging muscles?
- A changing view of bone marrow cells
- New finding points to potential options for attacking stem cells in triple-negative breast cancer
When human umbilical cord blood cells were transplanted into rats that had undergone a simulated myocardial infarction (MI), researchers investigating the long term effects of the transplantation found that left ventricular (LV) heart function in the treated rats was improved over those that did not get the stem cells. The animals were maintained without immunosuppressive therapy.
Harvard stem cell scientists have successfully converted skins cells from patients with early-onset Alzheimer’s into the types of neurons that are affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells. This may also make it possible to develop therapies far more quickly and accurately than before.
Adult stem cells and cancer cells have many things in common, including an ability to migrate through tiny gaps in tissue. Both types of cells also experience a trade-off when it comes to this ability; having a flexible nucleus makes migration easier but is worse at protecting the nucleus’ DNA compared to a stiffer nucleus. Nuclear proteins that regulate nuclear stiffness are therefore thought to control processes as diverse as tissue repair and tumor growth.
UT Southwestern Medical Center researchers created new nerve cells in the brains and spinal cords of living mammals without the need for stem cell transplants to replenish lost cells.
We are a product of our parents. Maybe you have your mother’s large, dark eyes, and you inherited your father’s infectious smile. Both parents contribute one copy, or allele, of each gene to their offspring, so that we have two copies of every gene for a given trait – one from mom, the other from dad. In general, both copies of a gene are switched on or off as an embryo develops into an adult. The “switching on” of a gene begins the process of gene expression that ultimately results in the production of a protein.
A study co-published in Nature Medicine this week by University of Toronto researcher Penney Gilbert has determined a stem cell based method for restoring strength to damaged skeletal muscles of the elderly.