- Blocking differentiation is enough to give cells ‘stemness’
- Investigators create complex kidney structures from human stem cells derived from adults
- Stem cell treatment lessens impairments caused by dementia with Lewy bodies
- A step forward in obtaining blood stem cells in laboratory
- Sleep deprivation affects stem cells, reducing transplant efficiency, study finds
- RNA’s part in determining the health of stem cells
- Aged neurons can now be generated using stem cell technology
- High dose chemo & stem cell transplantation results in long-term survival for amyloid patients
Stem Cell TutorialPotential uses of human stem cells and the obstacles that must be overcome A deeper look at induced pluripotent stem cells Comparing similarities and differences between embryonic and adult stem cells Describing adult stem cells What are embryonic stem cells and how are they grown? What are the unique properties of stem cells that make them so special?
Though immune therapy and regenerative medicine are promising areas of research for future medical therapies, they are limited today by the difficulty of creating stem cells, and scientists around the world are searching for ways to create somatic stem cells in the easiest way possible. Now, a collaboration between the RIKEN Center for Integrative Medical Science (IMS) and other institutions in Japan and Europe have found that in immune cells, simply blocking a transcription factor that leads to differentiation is sufficient to keep cells in a multipotent stem cell-like state where they can continue to proliferate and can later differentiate into various cell types.
Investigators at Brigham and Women’s Hospital (BWH) and the Harvard Stem Cell Institute (HSCI) have established a highly efficient method for making kidney structures from stem cells that are derived from skin taken from patients. The kidney structures formed could be used to study abnormalities of kidney development, chronic kidney disease, the effects of toxic drugs, and be incorporated into bioengineered devices to treat patients with acute and chronic kidney injury. In the longer term, these methods could hasten progress toward replacing a damaged or diseased kidney with tissue derived from a patient’s own cells. These results were published in Nature Biotechnology this week.
Neural stem cells transplanted into damaged brain sites in mice dramatically improved both motor and cognitive impairments associated with dementia with Lewy bodies, according to University of California, Irvine neurobiologists with the Sue & Bill Gross Stem Cell Research Center and the Institute for Memory Impairments and Neurological Disorders.
An international study led by researchers from IMIM (Hospital del Mar Medical Research Institute) published in the journal Nature Communications has revealed that the intensity or efficiency of the activation of a protein called Notch, which is involved in the different phases of embryonic development, determines the fate of cells, i.e. if cells will form the aorta artery or blood (hematopoietic) stem cells. For artery cells, many Notch molecules need to be activated, whereas for hematopoietic cells many fewer are needed.
Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine.
What makes stem cells so interesting is that they are pluripotent: they have the potential to become any cell in an organism. Their ability to differentiate into any cell and be used to replace those that are damaged or diseased holds promise, but only once the secret to controlling them has been unlocked.