- Scientists accelerate aging in stem cells to study age-related diseases like Parkinson’s
- New report on stem cell research reveals the field is growing twice as fast as the world average
- Prostate cancer stem cells are a moving target, UCLA researchers say
- The heart’s own stem cells play their part in regeneration
- Researchers unlock a new means of growing intestinal stem cells
- Colon cancer researchers target stem cells, discover viable new therapeutic path
- Human stem cells converted to functional lung cells
- Scientists design and test new approach for corneal stem cell treatments
Stem cells hold promise for understanding and treating neurodegenerative diseases, but so far they have failed to accurately model disorders that occur late in life. A study published by Cell Press December 5th in the journal Cell Stem Cell has revealed a new method for converting induced pluripotent stem cells (iPSCs) into nerve cells that recapitulate features associated with aging as well as Parkinson’s disease. The simple approach, which involves exposing iPSC-derived cells to a protein associated with premature aging called progerin, could enable scientists to use stem cells to model a range of late-onset disorders, opening new avenues for preventing and treating these devastating diseases.
Elsevier, EuroStemCell, and Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS), today released “Stem Cell Research report: Trends and Perspectives on the Evolving International Landscape” at the World Stem Cell Summit. This new, comprehensive analysis of the growth and development of the stem cell field as a whole, closely examines the research landscape for embryonic stem (ES) cell, human embryonic stem (hES) cell and induced pluripotent stem (iPS) cell.
UCLA researchers have discovered how prostate cancer stem cells evolve as the disease progresses, a finding that could help point the way to more highly targeted therapies.
Up until a few years ago, the common school of thought held that the mammalian heart had very little regenerative capacity. However, scientists now know that heart muscle cells constantly regenerate, albeit at a very low rate. Researchers at the Max Planck Institute for Heart and Lung Research in Bad Nauheim, have identified a stem cell population responsible for this regeneration. Hopes are growing that it will be possible in future to stimulate the self-healing powers of patients with diseases and disorders of the heart muscle, and thus develop new potential treatments.
Researchers at MIT and Brigham and Women’s Hospital have shown that they can grow unlimited quantities of intestinal stem cells, then stimulate them to develop into nearly pure populations of different types of mature intestinal cells. Using these cells, scientists could develop and test new drugs to treat diseases such as ulcerative colitis.
Scientists and surgeons at Princess Margaret Cancer Centre have discovered a promising new approach to treating colorectal cancer by disarming the gene that drives self-renewal in stem cells that are the root cause of disease, resistance to treatment and relapse. Colorectal cancer is the third leading cause of cancer-related death in the Western world.