- Stem cells may improve tendon healing, reduce retear risk in rotator cuff surgery
- Scientists coax stem cells to form 3-D mini lungs
- TSRI team discovers enzyme that keeps blood stem cells functional to prevent anemia
- Scientists pinpoint molecule that switches on stem cell genes
- First stem cell-based approach to treat type 2 diabetes effective in mice
- Scientists grow ‘mini-lungs’ to aid the study of cystic fibrosis
- Stem cells help researchers peg rabies resistance
- OSKM stoichiometry determines iPS cell reprogramming
An injection of a patient’s bone marrow stem cells during rotator cuff surgery significantly improved healing and tendon durability, according to a study presented today at the 2015 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS).
Scientists have coaxed stem cells to grow the first three-dimensional mini lungs.
Previous research has focused on deriving lung tissue from flat cell systems or growing cells onto scaffolds made from donated organs.
Stem cells can generate any type of cell in the body, but they are inactive most of the time–and for good reason. When stem cells become too active and divide too often, they risk acquiring cell damage and mutations. In the case of blood stem cells (also called hematopoietic stem cells or HSCs), this can lead to blood cancers, a loss of blood cells and an impaired ability to fight disease.
Stem cells can have a strong sense of identity. Taken out of their home in the hair follicle, for example, and grown in culture, these cells remain true to themselves. After waiting in limbo, these cultured cells become capable of regenerating follicles and other skin structures once transplanted back into skin. It’s not clear just how these stem cells — and others elsewhere in the body — retain their ability to produce new tissue and heal wounds, even under extraordinary conditions.
A combination of human stem cell transplantation and antidiabetic drugs proved to be highly effective at improving body weight and glucose metabolism in a mouse model of type 2 diabetes. The findings, published March 19th by Stem Cell Reports, could set the stage for clinical trials to test the first stem cell-based approach for insulin replacement in patients with type 2 diabetes.
Scientists at the University of Cambridge have successfully created ‘mini-lungs’ using stem cells derived from skin cells of patients with cystic fibrosis, and have shown that these can be used to test potential new drugs for this debilitating lung disease.